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Hong-Zhuan Chen Selected Research

Muscarinic Agonists

8/2013Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2.
2/2006Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle.
7/2003Differentiating effects of anisodamine on cognitive amelioration and peripheral muscarinic side effects induced by pilocarpine in mice.

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Hong-Zhuan Chen Research Topics

Disease

46Neoplasms (Cancer)
03/2022 - 01/2006
20Alzheimer Disease (Alzheimer's Disease)
08/2021 - 07/2003
10Neoplasm Metastasis (Metastasis)
01/2021 - 01/2014
7Glaucoma
02/2021 - 02/2006
7Cognitive Dysfunction
01/2019 - 12/2005
5Memory Disorders (Memory Loss)
08/2021 - 07/2003
5Ischemia
02/2021 - 07/2005
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 09/2016
4Lung Neoplasms (Lung Cancer)
10/2021 - 09/2017
4Adenocarcinoma of Lung
01/2021 - 01/2018
4Glioblastoma (Glioblastoma Multiforme)
01/2019 - 05/2015
4Inflammation (Inflammations)
09/2017 - 04/2008
3Breast Neoplasms (Breast Cancer)
01/2022 - 03/2010
3Colorectal Neoplasms (Colorectal Cancer)
06/2021 - 01/2014
3Chronic Obstructive Pulmonary Disease (COPD)
01/2019 - 01/2015
3Pathologic Processes
01/2019 - 01/2016
3Hypoxia (Hypoxemia)
08/2018 - 01/2017
3Glioma (Gliomas)
02/2013 - 09/2002
3Brain Ischemia (Cerebral Ischemia)
09/2012 - 01/2004
2COVID-19
04/2022 - 03/2021
2Melanoma (Melanoma, Malignant)
03/2022 - 03/2014
2Stomach Neoplasms (Stomach Cancer)
11/2021 - 10/2018
2Gallbladder Neoplasms (Gallbladder Cancer)
08/2021 - 11/2019
2Neuroinflammatory Diseases
01/2021 - 11/2009
2Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 01/2006
2Dementia (Dementias)
05/2020 - 02/2014
2Adenocarcinoma
09/2017 - 08/2013
2Pneumonia (Pneumonitis)
01/2016 - 11/2012
2Necrosis
02/2015 - 03/2010
2Asthma (Bronchial Asthma)
06/2013 - 02/2011
2Neurodegenerative Diseases (Neurodegenerative Disease)
02/2012 - 07/2005
2Sialorrhea
12/2009 - 07/2003
2Gastroesophageal Reflux (GERD)
04/2008 - 11/2007
2Neuroblastoma
02/2007 - 12/2005

Drug/Important Bio-Agent (IBA)

18Pharmaceutical PreparationsIBA
03/2022 - 04/2009
8Peptides (Polypeptides)IBA
01/2021 - 11/2003
7Proteins (Proteins, Gene)FDA Link
01/2021 - 11/2003
7Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
05/2020 - 04/2008
6Angiogenesis InhibitorsIBA
01/2016 - 03/2010
5EnzymesIBA
03/2022 - 01/2018
5Amyloid (Amyloid Fibrils)IBA
08/2021 - 11/2003
5Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2021 - 01/2018
5LigandsIBA
09/2016 - 11/2009
5Paclitaxel (Taxol)FDA LinkGeneric
01/2016 - 03/2010
4Glucose (Dextrose)FDA LinkGeneric
02/2021 - 01/2004
4Neuroprotective AgentsIBA
02/2021 - 09/2009
4satropaneIBA
01/2017 - 11/2008
3Tyrosine Kinase InhibitorsIBA
10/2021 - 01/2018
3ErbB Receptors (EGF Receptor)IBA
10/2021 - 01/2018
3Oxygen (Dioxygen)IBA
02/2021 - 01/2004
3Retinaldehyde (Retinal)IBA
02/2021 - 03/2014
3Phosphoglycerate Mutase (Phosphoglyceromutase)IBA
01/2021 - 12/2019
3Indicators and Reagents (Reagents)IBA
01/2021 - 10/2018
3CytokinesIBA
10/2019 - 06/2013
3SteroidsIBA
01/2019 - 01/2015
3Small Interfering RNA (siRNA)IBA
08/2018 - 10/2017
3RNA (Ribonucleic Acid)IBA
01/2018 - 09/2017
3Pilocarpine (Ocusert)FDA LinkGeneric
03/2014 - 07/2003
3Scopolamine (Hyoscine)FDA Link
02/2014 - 07/2003
3Cholinergic Agents (Cholinergics)IBA
02/2014 - 07/2003
3Muscarinic AgonistsIBA
08/2013 - 07/2003
3Desipramine (Pertofrane)FDA LinkGeneric
02/2013 - 09/2002
3Antidepressive Agents (Antidepressants)IBA
02/2013 - 09/2009
2AcidsIBA
03/2022 - 04/2008
2Oxidoreductases (Dehydrogenase)IBA
11/2021 - 08/2018
2Reactive Oxygen Species (Oxygen Radicals)IBA
10/2021 - 01/2019
2Photosensitizing Agents (Photosensitizers)IBA
09/2021 - 08/2018
21-phenyl-3,3-dimethyltriazene (PDT)IBA
09/2021 - 01/2021
2Long Noncoding RNAIBA
08/2021 - 11/2019
2Biomarkers (Surrogate Marker)IBA
08/2021 - 01/2019
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
08/2021 - 01/2021
2asparaginylendopeptidase (legumain)IBA
08/2021 - 01/2021
2huperzine AIBA
02/2021 - 04/2009
2Biological ProductsIBA
01/2021 - 02/2020
2HKB99IBA
01/2021 - 12/2019
2Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA
01/2021 - 01/2018
2Lipoproteins (Lipoprotein)IBA
02/2020 - 10/2017
2Gefitinib (Iressa)FDA Link
12/2019 - 09/2017
2Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2019 - 01/2006
2Aldehyde DehydrogenaseIBA
01/2019 - 09/2017
2Matrix Metalloproteinases (MMPs)IBA
01/2019 - 01/2016
2HDL LipoproteinsIBA
10/2017 - 12/2016
2ApolipoproteinsIBA
10/2017 - 12/2016
2Interleukin-6 (Interleukin 6)IBA
09/2017 - 11/2012
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2017 - 01/2006
2Apolipoproteins E (ApoE)IBA
01/2016 - 01/2015
2Nanoparticle Drug Delivery SystemIBA
08/2015 - 03/2014
2TriterpenesIBA
01/2015 - 02/2013
2Caspase 3 (Caspase-3)IBA
03/2014 - 09/2002
2Docetaxel (Taxotere)FDA Link
03/2014 - 05/2013
2OvalbuminIBA
06/2013 - 02/2011
2anisodamineIBA
07/2012 - 02/2011
2Amyloid beta-PeptidesIBA
11/2009 - 11/2003
2Cholinesterase Inhibitors (Anticholinesterases)IBA
04/2009 - 12/2005
2Single-Chain AntibodiesIBA
04/2009 - 03/2008

Therapy/Procedure

33Therapeutics
03/2022 - 07/2005
10Drug Therapy (Chemotherapy)
03/2022 - 03/2010
3Photochemotherapy (Photodynamic Therapy)
09/2021 - 08/2018
2Immunotherapy
01/2022 - 03/2008
2Combination Drug Therapy (Combination Chemotherapy)
01/2016 - 02/2011